In the 2024 Bioinformatics and Synthetic Biology (BIOS) competition organized by Synbio.id from August to December 2024, UGM Biology students once again achieved remarkable success, securing a gold medal and the position of Undergraduate Runner-Up. The two students, Muhammad Ode Rahmadhani (Class of 2021) and Renada Oktavia (Class of 2021), were part of Team Can-Con, which collaborated with students from various universities: Rafly Mochamad Rivaldo from the Faculty of Medicine, Universitas Padjadjaran; Tristan Kenneth Yudhistira from the Faculty of Medicine, Universitas Brawijaya; Zaki Sidqi Aaliyya from the Faculty of Medicine, Universitas Jenderal Soedirman; and Yonathan Henry Christianto, Bryan Wu, and Ruby Belinda Gunadi from the Faculty of Computer Science, Universitas Bina Nusantara. The team, led by Muhammad Ode Rahmadhani and guided by Prof. Dr. Yekti Asih Purwestri, M.Si., explored the compound phloroglucinol’s anticancer potential against non-small cell lung cancer (NSCLC) using an in-silico metabolomics approach.
This research addressed the pressing need to discover new anticancer compounds due to the increasing prevalence of multidrug resistance and the significant side effects associated with current cancer therapies. Notably, the potential of phloroglucinol as an anticancer agent against NSCLC remains unexplored. The study aimed to unravel the pharmacological network and interactions between phloroglucinol and proteins associated with NSCLC progression. This focus is crucial as NSCLC remains one of the leading causes of cancer-related deaths in Indonesia.
The research, conducted throughout the competition, lasted from August to late November 2024. On December 1, 2024, during Synbiotechfest 2024, which also served as the Awarding Ceremony, Team Can-Con was announced as the gold medal winner and Undergraduate Runner-Up.
This outstanding achievement was made possible through the multidisciplinary collaboration of researchers from diverse academic backgrounds, which united diverse perspectives and approaches to develop a comprehensive study.
Author: M. Ode Rahmadhani