• Home
  • Achivements
  • page. 3
Arsip:

Achivements

UGM Students Offer Dayak Onion as an Effective Treatment for Tongue Cancer

AchivementsNews ReleaseStudent Activities Thursday, 18 July 2024

Universitas Gadjah Mada students Ribka Wijayanti and Dwina Aulia (Dentistry 2022), Anisah Qurrotu Aini (Biology 2022), and Naila Nurfadhilah (Pharmacy 2022) conducted research on the potential of Dayak onion as an antiproliferative and apoptosis-inducing agent for human tongue cancer cells – under the guidance of Prof. drg. Supriatno, M.Kes., MD.Sc., Ph.D..


Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is a medicinal herb commonly used by the indigenous Dayak people and can be cultivated in various regions. Besides health benefits, this research also positively impacts the local economy. This research focuses on developing a natural therapy for tongue cancer by addressing the shortcomings of existing therapy. Plant-derived exosome-like nanoparticles, or PDENs, from Dayak onion, serve as a drug delivery method derived from Dayak onion exosomes.

“Cancer occurs due to the activity of proto-oncogenes, leading to excessive cell proliferation and the inhibition of tumor suppressor genes. We used PDENs because they have proven to inhibit proliferation and induce apoptosis in various types of cancer. Based on this, we wanted to explore its potential for tongue cancer treatment, ‘’ explained Ribka.

Ribka noted that using PDENs from Dayak onion induced apoptosis (programmed cell death) in cancer cells and reduced the number of proliferating cells.

“Dayak onions have a powerful IC50 equivalent to 38.97 ppm. This value is superior to other medicinal plants, such as soursop leaves and bajakah roots. The various therapeutic compounds in Dayak onion cannot be utilized as therapeutic agents using common extraction methods. However, with PDENs, all therapeutic compounds can be delivered to the target organ,” Anisah elaborated.

This research project was submitted as part of the Student Creativity Program in Exact Research (PKM-RE) with research funding support from the Ministry of Education, Culture, Research, and Technology (Kemendikbudristek) to conduct in-depth research and analysis on the potential of PDENs extract from Dayak onion. It hoped that this interdisciplinary collaborative research can inspire further exploration of natural potentials to improve human quality of life. [Writer: AQA]

UGM Students Offer Dayak Onion as an Effective Treatment for Tongue Cancer

AchivementsNews ReleaseStudent Activities Thursday, 18 July 2024

Universitas Gadjah Mada students Ribka Wijayanti and Dwina Aulia (Dentistry 2022), Anisah Qurrotu Aini (Biology 2022), and Naila Nurfadhilah (Pharmacy 2022) conducted research on the potential of Dayak onion as an antiproliferative and apoptosis-inducing agent for human tongue cancer cells – under the guidance of Prof. drg. Supriatno, M.Kes., MD.Sc., Ph.D..


Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is a medicinal herb commonly used by the indigenous Dayak people and can be cultivated in various regions. Besides health benefits, this research also positively impacts the local economy. This research focuses on developing a natural therapy for tongue cancer by addressing the shortcomings of existing therapy. Plant-derived exosome-like nanoparticles, or PDENs, from Dayak onion, serve as a drug delivery method derived from Dayak onion exosomes.

“Cancer occurs due to the activity of proto-oncogenes, leading to excessive cell proliferation and the inhibition of tumor suppressor genes. We used PDENs because they have proven to inhibit proliferation and induce apoptosis in various types of cancer. Based on this, we wanted to explore its potential for tongue cancer treatment, ‘’ explained Ribka.

Ribka noted that using PDENs from Dayak onion induced apoptosis (programmed cell death) in cancer cells and reduced the number of proliferating cells.

“Dayak onions have a powerful IC50 equivalent to 38.97 ppm. This value is superior to other medicinal plants, such as soursop leaves and bajakah roots. The various therapeutic compounds in Dayak onion cannot be utilized as therapeutic agents using common extraction methods. However, with PDENs, all therapeutic compounds can be delivered to the target organ,” Anisah elaborated.

This research project was submitted as part of the Student Creativity Program in Exact Research (PKM-RE) with research funding support from the Ministry of Education, Culture, Research, and Technology (Kemendikbudristek) to conduct in-depth research and analysis on the potential of PDENs extract from Dayak onion. It hoped that this interdisciplinary collaborative research can inspire further exploration of natural potentials to improve human quality of life. [Writer: AQA]

UGM Biology and Pharmacy Students Create Topical Patch Combining Fish Oil and Sugarcane Bagasse Biosilica for Diabetic Wound Healing

AchivementsNews Release Thursday, 18 July 2024

Diabetes mellitus (DM) is a global public health issue that can lead to macrovascular and microvascular complications. In Indonesia, the prevalence of DM among adults reaches 10.6%. Ineffective DM management can result in long-term metabolic, neurological, or vascular complications, making DM patients more susceptible to foot infections, which can increase the incidence of amputations. According to data from the Ministry of Health 2023, over one million DM patients in Indonesia have undergone foot amputations, with approximately 80% of these amputations beginning with foot ulcers. The prolonged infection of diabetic wounds is caused by high blood glucose levels, which increase bacterial proliferation. This issue exacerbated by immune system deficiencies, leading to restricted mobility and decreased daily productivity.


Based on this issue, Biology and Pharmacy UGM students Zahwa Khoirun Nisa (Biology 2022), Zatun Nithoghani Hafni (Biology 2021), Muhammad Nur Ikhsan (Biology 2021), Sekar Ayu Kusumawardani (Pharmacy 2022) and Alvian Chesyar Burhanudin (Pharmacy 2022) was developed a topical patch using two local Indonesian natural products: catfish oil and sugarcane bagasse biosilica, as an alternative treatment for diabetic wounds under guidance Dr. Adhyatmika, M.Biotech. This research, funded by the Ministry of Education and Culture, is part of the Student Creativity Program in Exact Research (PKM-RE).

The regular treatment for diabetic wounds is antibiotic therapy. However, excessive use of antibiotics can lead to antibiotic resistance, making treatment less effective. “We chose the patch formulation in this study to prevent excessive use of antibiotics while ensuring drug delivery to the wound with a more measured and controlled dosage,” said Zahwa. Hafni added that the patch formulation is also suitable for patients who cannot tolerate oral medications and avoids the first-pass effect, maintaining the bioavailability of the drug.

Catfish oil contains essential omega-3 fatty acids known to aid in wound healing. An innovation in this study involves adding sugarcane bagasse biosilica to the patch formulation. This biosilica has shown to possess antibacterial activity that supports wound healing.

The bagasse used obtained from the sugarcane milling residues at PT. Madubaru. “We collected the accumulated sugarcane bagasse, then subjected it to furnace treatment at 600°C for 1 hour. The resulting bagasse ash was then dissolved in NaOH and acidified with HCl to form a gel. This gel was then oven-dried to produce silica powder,” explained Ikhsan. The resulting biosilica was combined with catfish oil to create three formulations with different active ingredient concentrations (catfish oil: biosilica), namely F1 = 25:75, F2 = 50:50 and F3 = 75:25. “We made nanoemulsions with these three formulations, measured their particle sizes, then added gel bases to form nanoemulgel, which processed into patch preparations,” Alvian elaborated.

The patches were then tested on diabetic mellitus model rats. “We inflicted wounds on diabetic model rats and applied different treatments, including the three patch formulations. Wound diameter observed from day 1 to day 7,” Sekar said. The data showed the significant effects of the patch treatments on diabetic wound healing. Based on these conclusions, further analysis identified Formulation 1 (25:75) as the best for aiding diabetic wound healing. This research is expected to provide a theoretical foundation for developing comprehensive therapies to accelerate diabetic wound healing. With this advancement, we hope to contribute to improving the quality of life for diabetes patients and help them achieve better health and well-being. [Author: Zahwa Khoirun Nisa]

UGM Biology and Pharmacy Students Create Topical Patch Combining Fish Oil and Sugarcane Bagasse Biosilica for Diabetic Wound Healing

AchivementsNews ReleaseStudent Activities Thursday, 18 July 2024

Diabetes mellitus (DM) is a global public health issue that can lead to macrovascular and microvascular complications. In Indonesia, the prevalence of DM among adults reaches 10.6%. Ineffective DM management can result in long-term metabolic, neurological, or vascular complications, making DM patients more susceptible to foot infections, which can increase the incidence of amputations. According to data from the Ministry of Health 2023, over one million DM patients in Indonesia have undergone foot amputations, with approximately 80% of these amputations beginning with foot ulcers. The prolonged infection of diabetic wounds is caused by high blood glucose levels, which increase bacterial proliferation. This issue exacerbated by immune system deficiencies, leading to restricted mobility and decreased daily productivity.


Based on this issue, Biology and Pharmacy UGM students Zahwa Khoirun Nisa (Biology 2022), Zatun Nithoghani Hafni (Biology 2021), Muhammad Nur Ikhsan (Biology 2021), Sekar Ayu Kusumawardani (Pharmacy 2022) and Alvian Chesyar Burhanudin (Pharmacy 2022) was developed a topical patch using two local Indonesian natural products: catfish oil and sugarcane bagasse biosilica, as an alternative treatment for diabetic wounds under guidance Dr. Adhyatmika, M.Biotech. This research, funded by the Ministry of Education and Culture, is part of the Student Creativity Program in Exact Research (PKM-RE).

The regular treatment for diabetic wounds is antibiotic therapy. However, excessive use of antibiotics can lead to antibiotic resistance, making treatment less effective. “We chose the patch formulation in this study to prevent excessive use of antibiotics while ensuring drug delivery to the wound with a more measured and controlled dosage,” said Zahwa. Hafni added that the patch formulation is also suitable for patients who cannot tolerate oral medications and avoids the first-pass effect, maintaining the bioavailability of the drug.

Catfish oil contains essential omega-3 fatty acids known to aid in wound healing. An innovation in this study involves adding sugarcane bagasse biosilica to the patch formulation. This biosilica has shown to possess antibacterial activity that supports wound healing.

The bagasse used obtained from the sugarcane milling residues at PT. Madubaru. “We collected the accumulated sugarcane bagasse, then subjected it to furnace treatment at 600°C for 1 hour. The resulting bagasse ash was then dissolved in NaOH and acidified with HCl to form a gel. This gel was then oven-dried to produce silica powder,” explained Ikhsan. The resulting biosilica was combined with catfish oil to create three formulations with different active ingredient concentrations (catfish oil: biosilica), namely F1 = 25:75, F2 = 50:50 and F3 = 75:25. “We made nanoemulsions with these three formulations, measured their particle sizes, then added gel bases to form nanoemulgel, which processed into patch preparations,” Alvian elaborated.

The patches were then tested on diabetic mellitus model rats. “We inflicted wounds on diabetic model rats and applied different treatments, including the three patch formulations. Wound diameter observed from day 1 to day 7,” Sekar said. The data showed the significant effects of the patch treatments on diabetic wound healing. Based on these conclusions, further analysis identified Formulation 1 (25:75) as the best for aiding diabetic wound healing. This research is expected to provide a theoretical foundation for developing comprehensive therapies to accelerate diabetic wound healing. With this advancement, we hope to contribute to improving the quality of life for diabetes patients and help them achieve better health and well-being. [Author: Zahwa Khoirun Nisa]

Yellow Onion Peel: A Promising Ingredient for Burn Treatment

AchivementsNews Release Monday, 15 July 2024

Burns are injuries involving tissue damage due to contact with heat, radiation, chemicals, or electricity. Burns are challenging to heal and require patient stabilization, infection prevention, and optimal functional recovery. Burn victims are at risk of infection and systemic complications, depending on the burn’s extent and depth, the patient’s age and overall condition, and any pre-existing conditions. In Indonesia, burns have a relatively high prevalence, affecting 1.3% of the entire population.


Recognizing the significance of developing burn treatments, UGM students have developed a new approach to address this issue. They utilized yellow onion skin waste in the form of bilayer nanofiber. This research was conducted by Acenofer team consisting of Naufal Ahmad Fauzy (Pharmacy 2021) as the leader, along with four colleagues: Zulfa Nailil Muna (Physics 2022), Puspita Nur Rahmawati (Biology 2022), Tika Nur Amini (Biology 2022), and Erwinda Dwi Chofifah (Biology 2022), under the guidance of Dr. Retno Murwanti, MP, Ph.D.

“In this research, we used yellow onion skins due to their high levels of quercetin and to preserve the environment. We modified the preparation into bilayer nanofibers to enhance extract penetration into the wound and prevent infection,” Naufal explained.

The research process involved various stages, including extraction, preparation, characterization, in vivo testing, and data analysis. Characterization performed using multiple parameters, including SEM analysis, FTIR, tensile strength test, and contact angle tests. In vivo testing followed by histopathological analysis to observe the healing process within the skin layers.

“Our research showed promising results. The nanofibers were successfully produced with good quality, were not easily damaged, had appropriately sized structures, and in vivo testing showed wound closure by the preparation,” Zulfa said.

This research is expected to become an alternative treatment by leveraging Indonesia’s natural resources, with further research advancing to clinical trials and commercialization for public use. [Writer: Erwinda Dwi Chofifah]

Innovative Solution for Environmental Impact Post-Tin Mining in Bangka Belitung, Biology Students Win 1st Runner-Up at AGRIXPLOSION UNS 2024 Essay Competition

AchivementsNews Release Tuesday, 9 July 2024

A team of undergraduate students from the Faculty of Biology, Universitas Gadjah Mada, class of 2022, led by Azra Belva Naprilian, along with Kotimah and Ridho Nur Alam, won 1st Runner-Up in the essay competition AGRIXPLOSION organized by the Faculty of Agriculture, Universitas Sebelas Maret Surakarta (UNS). The competition, sponsored by Pertamina, revolved around the theme “Implementing Innovation to Reach Net Zero Emission for a Sustainable Future” featured participants from various universities across Indonesia. The competition included several stages: administration and essay submission, followed by an online presentation on Sunday, June 30, 2024.


In this competition, the biology team presented an essay titled “Utilization of Biofertilizer and Spirulina sp. as Micro-remediators in the Conservation Efforts of Acacia mangium Forests in Post-Tin Mining Ecosystems in Bangka Belitung,” under the guidance of Tyas Ikhsan Hikmawan, M.Sc., Ph.D. This innovation addresses the environmental damage caused in Bangka Belitung, the largest tin-producing region, where natural resource exploitation without maintenance efforts has led to ecosystem pollution. The essay proposed a biofertilizer formula combining various microbes capable of micro-remediation of post-mining land. Additionally, the innovation included using a combination of biofertilizer and Spirulina sp. to enhance biofertilizer as a supplementary nutrient provider for microorganisms within it.

Reclamation of post-tin mining land in Bangka Belitung is a crucial step in addressing ecosystem damage caused by mining activities. The combination of micro-remediators and the utilization of microalgae Spirulina sp. can effectively remediate heavy metals. Moreover, biofertilizers can restore essential nutrients and improve soil structure. The planting of Acacia mangium as a phytoremediator has also proven effective in restoring the balance of ecosystems in former mining lands, given its adaptability to heavy metal-contaminated soils. This innovation is expected to minimize the negative impacts of mining and support forest conservation and environmental sustainability in the region. This strategy aligns with The Sustainable Development Goals (SDGs) point 15, related to sustainable management of post-mining land, ensuring ecological recovery, and soil productivity for the future.

[Authors: Azra Belva Naprilian and Kotimah]

Student Team From Gadjah Mada University Faculty of Biology Wins 3rd Place in CEWAMA Research Competition

Achivements Wednesday, 3 July 2024

Yogyakarta, July 1, 2024 – A team of students from the Faculty of Biology at Gadjah Mada University has achieved remarkable success by winning 3rd place in the CEWAMA Research Competition organized by the Indonesian Aviation Polytechnic Curug. This national competition ran from May 29 to June 25, 2024, for the scientific writing phase and concluded with final presentations on July 1, 2024.

The team, named “ALNOCO” (Algae Non Carbon), consists of K. William Hendri Panjaitan (class of 2021), K.H. Mahadhevy Ryrathna Vidhantyka (class of 2022), and Aqil Muhammad Hafiz (class of 2021). Under the guidance of Dr. Eng. Thoriq Teja Samudra, M.Sc., and Dr. Eko Agus Suyono, M.App.Sc., they presented a paper titled “INNOVATION OF POME AS A MICROALGAE (Neochloris oleoabundans) SUBSTRATE FOR DIVERSIFICATION OF RENEWABLE AND ENVIRONMENTALLY FRIENDLY AIRCRAFT FUEL DERIVATIVES.”

In their work, the ALNOCO team addressed the issue of alternative bioavtur from microalgae biomass by utilizing waste POME (Palm Oil Mill Effluent) as a growth substrate. The biomass of N. oleoabundans, which is rich in lipid content, can be used as an environmentally friendly and renewable alternative for aircraft fuel. The growth and lipid content of N. oleoabundans are influenced by various factors, including optimal nutritional content (N:P:C). POME waste provides the necessary N:P:C levels for N. oleoabundans to grow and accumulate lipids in its cells.

This innovation has significant potential to support environmentally friendly bioavtur production before 2030, with the support of all parties involved in the next stages of testing, including preparing a roadmap for commercialization, However, further discussion is needed to optimize the growth of microalgae in POME waste and extract lipids for making aircraft fuel that minimally pollutes the air. Additionally, the use of microalgae and POME as alternative options has been proven to be safe to process, fulfilling the need for a clean energy transportation system, which will positively impact the environment.

The competition was attended by 56 teams from various universities across Indonesia. The achievements of the ALNOCO team demonstrate their commitment to developing innovative and applicable research. This success also showcases the Faculty of Biology at Gadjah Mada University’s ongoing efforts to contribute to the development of sustainable science and technology, aligning with UGM’s SDGs goals in the renewable energy field.

Biology Students Win 1st Place at OGG FITB ITB 2024 Essay Competition with Innovative Self-Pigmented Biotextile for Green Industrial Revolution

AchivementsNews Release Wednesday, 26 June 2024

Over the past decade, the Textile and Textile Products (TPT) industry in Indonesia has risen sharply alongside the increasing demand for clothing and lifestyle needs. However, the textile industry still relies on conventional methods that produce hazardous waste, especially from the dyeing process, which is the most significant contributor to environmental waste. Moreover, the current management of Wastewater Treatment Plants (IPAL) has not effectively handled the waste produced.


Driven by these concerns, Erwinda Dwi Chofifah and Kotimah, students from the Faculty of Biology, class of 2022, initiated a solution focusing on the upstream production process of textiles by creating an eco-friendly biomaterial based on bacterial cellulose with the ability to produce color pigments (self-pigmented biotextile). Under the guidance of Tyas Ikhsan Hikmawan, S.Si., M.S., Ph.D., this innovation, named I-CHERA, was introduced at the essay competition of the Geography and Geoscience Olympiad (OGG) organized by the Faculty of Earth Sciences and Technology (FITB) at the Bandung Institute of Technology (ITB).

After passing a series of administrative and document selections, I-CHERA made it into the top 10 best works and had the opportunity to be presented in person on June 21-23, 2024, at ITB. Targeting the sub-theme “Green Industrial Revolution through Sustainable Industrialization Practices,” I-CHERA outperformed other projects proposed by hundreds of student teams from various universities across Indonesia and won 1st place. Erwinda and Kotimah hope this innovation will help Indonesia realize a green industrial revolution in the future.

IUP Biology Alumni, Faculty of Biology UGM, Receive 2024 LPDP Scholarship

AchivementsNews Release Friday, 14 June 2024

LPDP (Indonesian Endowment Fund for Education) once again presents prestigious educational opportunities for IUP Biology graduates. Julio Jonah Lengkong Worang and Aisyah Rahmah Tantri, two talented and dedicated IUP Biology alumni from the class of 2019, have successfully received LPDP scholarships to pursue their master program abroad. Julio will continue his studies at the National University of Singapore (NUS) in Singapore, while Aisyah will continue her studies at the University of Edinburgh in Scotland.


These two outstanding students have demonstrated their commitment to science and self-development since the beginning of their studies in the IUP Biology program. The LPDP scholarships that they received are as recognition of their academic achievements and leadership throughout their studies.

Julio Jonah Lengkong Worang has been accepted to the National University of Singapore (NUS) to pursue a Masters in Biodiversity Conservation and Sustainability, starting on 5 August 2024. The one-year program is renowned for its focus on global issues and nature-based climate change solutions. Julio said that the curriculum at NUS focuses on current world issues and practical nature-based climate solutions, facilitating students with necessary on-field skills, including technological-driven innovations to assist in the field of conservation. “I am very grateful to LPDP for their tremendous support. This is a great opportunity for me to continue to grow and contribute in the field of biology,” said Julio.

Meanwhile, Aisyah, who is known for her sensitivity to environmental and sustainability issues, will broaden her horizons at the University of Edinburgh in the Masters for Quantitative Genetics and Genome Analysis. “Receiving the LPDP scholarship is a great honor for me. The application process was challenging, required hard work, and a strong vision for my future. I am grateful to have received tremendous support from the faculty and fellow alumni, who guided me through it. With this scholarship, I am excited to pursue my aspirations and make a positive impact in Indonesia,” said Aisyah enthusiastically.

Head of Undergraduate Program, Faculty of Biology UGM, Sukirno, M.Sc., Phd and IUP Biology Manager, Nur Indah Septriani, M.Sc., Ph.D. expressed their acknowledge for Julio and Aisyah, and their belief that they will success. “We are very proud to see the achievements of these two IUP Biology alumni. This is an extraordinary example of their dedication and resilience in pursuing their dreams,” said Sukirno.

LPDP is committed to continuing to support higher education in Indonesia by providing scholarships to potential and dedicated students like Julio and Aisyah. This scholarship not only opens the door to quality education abroad, but also builds a broad professional network to support Indonesia’s progress in the future.
To Julio and Aisyah, we congratulate them on their incredible achievements, and we hope that they will continue to inspire future generations to pursue their dreams with the same passion and determination.[aulia]

Biology Students Win Bronze Medal and Favorite Poster at National FAPERTA FAIR 5 with Futuristic Innovation for Disease Detection in Rice Plants (Oryza sativa L.)

AchivementsNews Release Wednesday, 5 June 2024

The issue of pathogens in rice plants is a focus of agricultural empowerment efforts in Indonesia. These pathogens cause disease outbreaks that lead to a decrease in rice productivity. To address this obstacle, some farmers tend to rely on pesticides without noticing the condition of the rice plants. As a result, their efforts were ineffective and posed a threat to environmental health due to chemical pollution from excessive pesticides.


Addressing this issue, Adzkiya Aqmaliza Rahmattillah and Sheva Rimma Dhanty, biology students from the class of 2021, innovated a smartphone-integrated smart scanning application based on Artificial Intelligence called ORYSMART. This application can detect diseases in rice plants and provide treatment recommendations, under the guidance of Dr. Wiko Arif Wibowo, S.Si. ORYSMART was introduced at the FAPERTA FAIR (Futuristic and Prestige Research, Technology, and Art) 5 competition at Dhyana Pura University, Denpasar, Bali, on May 18-19, 2024. In its fifth batch, FAPERTA FAIR carried the theme “The Role of Young Innovators in Facing Global Competition to Welcome Golden Indonesia 2045.” At the event, Adzkiya and Sheva, with ORYSMART, won the Bronze Medal and the Favorite Poster Award in the Technology subtheme as a futuristic innovative solution that can help address diseases in rice plants. With its scanning and recognition capabilities, ORYSMART can detect the type, symptoms, causes, and handling solutions for rice plant diseases. The application offers advanced analysis that combines human and artificial intelligence, providing more accurate disease analysis and effective handling solutions. ORYSMART also facilitates access to consultations with experienced and reliable plant protection experts.

This application aimed to empower rice farmers in Indonesia to manage their fields better and more effectively. Therefore, ORYSMART is designed to be practical and easy to use, especially for users who are not yet familiar with the technology. This innovation is expected to be a significant step in agricultural empowerment in Indonesia, supporting national food security towards Golden Indonesia 2045. This innovation and idea also contribute to achieving SDG 2 (zero hunger) by improving rice productivity, the staple food for most Indonesians. [Author: Sheva Rimma Dhanty]