Colon cancer originates from the longest part of the large intestine. Its incidence ranks third worldwide, and it is projected to increase by 63% by 2040. However, current treatments for colon cancer, including surgery, radiotherapy, and chemotherapy, tend to cause high toxicity and yield unsatisfactory results. Developing a safer treatment for colon cancer with minimal side effects remains a challenge. This issue motivated five UGM students, part of the PKM-RE Team that qualified for PIMNAS 2023—Atikah Nurunnissa’, Anisa Dewi Rahayu, Lathief Al Umami, Ilma Tazkiya, and Dwi Ardyan Syah Mustofa from the Faculty of Biology, along with their supervising lecturer, Woro Anindito Sri Tunjung, S.Si., M.Sc., Ph.D., to explore natural substances as a safer alternative for colon cancer treatment.

Anisa explained that pineapples are abundant in Indonesia, ranking fourth among the world’s largest pineapple producers. The core, skin, and crown of pineapples contribute 50% of the total weight of the fruit. Surprisingly, these parts contain phenolic compounds, terpenoids, and bromelain enzymes with potential anti-cancer properties. The application of pineapple core, skin, and crown for anti-cancer purposes involves a fermentation process to break down complex compounds into derivative compounds. Rhizopus.oryzae is used as a fermentation starter to enhance the value and content of anti-cancer compounds, specifically targeting colon cancer. Successful fermentation processes have demonstrated the production of more specific derivative anti-cancer compounds. [Author: Anisa Dewi Rahayu]

Biology students Universitas Gadjah Mada (S1) made another achievement at the 2nd International Conference of Biology for Students (ICOBIOS) X Open Bioproject Competition (OBC) 2023 held at Brawijaya University on November 12-14, 2023. This remarkable achievement was achieved by Denova Team composed of Darren Nicholas Rahmanto (Biologi 2021) and Muhammad Naufal Dzakwan Luzen (Biologi 2021) under guidance of Dr. Aprilia Sufi Subiastuti, S.Si.

The 2nd International Conference of Biology for Students (ICOBIOS) x Open Bioproject Competition (OBC) 2023 has the theme ”Inovative Approach in Investigating Biological Problem through Multidisciplinary Research and Startup” aimed to accelerate collaboration and enhance understanding of various biological aspect for young researchers. The competition was held from July to November 2023 and had several stages, including abstract submission, abstract announcement, proposal submission, presentation and ceremonial event.

The Denova team addresses the widespread occurrence of potato diseases caused by Streptomyces scabies, significantly reducing potato production productivity. Therefore, the team proposes a solution to expedite and enhance the sensitivity of detecting Streptomyces scabies in potatoes. It is hoped that with this innovation, farmers can implement this improved detection method, optimizing potato productivity.

UGM students have successfully discovered the neuroprotective benefits of Javanese chili kombucha as a functional beverage for Diabetes Mellitus (DM) patients at risk of Alzheimer’s Disease (AD). This research was led by Eri Dwi Suyanti along with Salma Mutiara Tsani, Fithratun Nastiti, Wafiq Hanifah, and Marcellino Maatita. The researchers, from various disciplines at UGM including medicine, biology, and pharmacy, collaborated to unveil the potential of Javanese chili kombucha in the medical field. This study was conducted under the guidance of dr. Arta Farmawati, Ph.D. The research focusing on Javanese chili was submitted under the Student Creativity Program for Exact Sciences (PKM-RE) and received funding support for the entire research process, from obtaining ethical clearance to experiment financing. The support was provided by the Ministry of Education, Culture, Research, and Technology (Kemendikbud Ristek).

Type 2 Diabetes Mellitus (T2DM) and AD are diseases with increasing prevalence as age advances. It’s predicted that by 2050, AD patients in Indonesia will reach 3,999,285. Unfortunately, current therapies for T2DM patients cause gastrointestinal side effects such as nausea and vomiting. Javanese chili contains the bioactive compound piperine, which has anti-diabetic effects and can be developed into a functional kombucha beverage. Kombucha is a fermented drink known for its anti-hyperglycemic effects. The research revealed that the bioactive compounds in Javanese chili kombucha exhibit significant benefits. Javanese chili kombucha could provide neuroprotective benefits by inhibiting an enzyme activity linked to AD in T2DM patients. Moreover, animal trials demonstrated that Javanese chili kombucha could maintain spatial memory in test mice. This study brings new hope in AD treatment through the natural wealth of Indonesia. The researchers aim to further this knowledge into clinical trials, envisioning a future where this research actively protects T2DM patients at risk of AD complications.[Author: Marcellino Maatita]

Universitas Gadjah Mada organized one of its annual events commemorating its 74th anniversary, the UGM Outstanding Individuals Awards Night 2023. The event took place on Wednesday, November 15, 2023, at Grha Sabha Pramana UGM. Dr. Andi Sandi Antonius Tabusassa Tonralipu, S.H., LL.M, the Secretary of UGM, reported that 72 individuals were honored at the UGM Outstanding Individuals Awards Night 2023. The categories of recognition included outstanding alumni, exemplary faculty and researchers, best publications, community service, Outstanding Lecturer UGM-Level, knowledge dissemination through documentary videos, innovative learning via MOOC, MBKM (Merdeka Belajar Kampus Merdeka) program coordinators, Outstanding staff, and Outstanding students.The Rector of UGM Prof. dr. Ova Emilia, M.Med.Ed., Sp.OG(K)., Ph.D., expressed that the purpose of these awards was to motivate and appreciate UGM’s alumni, community, and all units at the university that have demonstrated outstanding contributions and performance, benefiting UGM and impacting the wider society.

The Faculty of Biology at UGM had a moment of pride as one of its lecturers, Ganies Riza Aristya, S.Si, M.Sc., Ph.D., was among the recipients. She received the award for Outstanding International Lecturer in the Field of Community Service. This recognition was earned through the “Smart Integrated Education System of Agrotourism Community Services” project, previously awarded as an Outstanding Flagship Project in the RCE (Regional Centre of Expertise) Awards for Innovative Projects on Education for Sustainable Development (ESD) 2023. The program highlighted agricultural potential in Sendangsari and Sidomulyo villages in Pengasih, Kulon Progo, involving UGM’s Community Service Program (KKN) team to build agriculture-based sustainable tourism villages. The contribution and participation of stakeholders and residents from both villages were key factors in the success of the program. Ganies Riza Aristya, S.Si, M.Sc., Ph.D expressed that the UGM Outstanding Individuals Award was an acknowledgment of the team’s efforts, particularly the KKN UGM student team, showcasing strategic issues, dedication, and synergy with the community. Furthermore, she hoped for continuous innovation, growth, and collaborative problem-solving in UGM’s community service activities, aiming to produce solutions collectively for societal challenges.

The Merck Young Scientist Award (MYSA) 2023 has announced the top 12 semifinalists on October 25, 2023. The MYSA program aims to engage young scientists in discussions, idea sharing, scientific research development, and collaboration to create new breakthroughs, while also recognizing the dedication of scientists in developing sustainable solutions to meet the healthcare needs of Indonesia’s society. Additionally, MYSA seeks to inspire and encourage young scientists to innovate in life sciences and provide solutions to various health challenges. This program, in its fifth year running since 2018, collaborates with the Research Organization for Life Sciences and the Environment, the National Research and Innovation Agency (BRIN), and Universitas Gadjah Mada, who act as the judging panel to provide optimal assessments of the participants.

The 12 semifinalists of the Merck Young Scientist Award (MYSA) 2023 come from various institutions including Institut Teknologi Sumatera, Sumbawa University of Technology, Universitas Gadjah Mada, Indonesia International Institute for Life Sciences, Universitas Indonesia, National Research and Innovation Agency (BRIN), IMERI FKUI, and PT Bio Farma. Participants were selected by a judging panel led by Prof. Dr. apt. Edy Meiyanto M.Si from the Faculty of Pharmacy, Universitas Gadjah Mada, including Iman Hidayat., Ph.D, Prof. Dr. Nurul Taufiqu Rochman., M.Eng., Ph.D from the National Research and Innovation Agency (BRIN), Ilma Equilibrina., Ph.D from Merck, and Dr. Riza Arief Putranto., D.E.A from The Indonesian Society for Bioinformatics & Biodiversity.

Through rigorous evaluation, Sigit Dwi Maryanto., S.Si., M.Sc from the Faculty of Biology, Universitas Gadjah Mada emerged as one of the top 12 semifinalists. His research focuses on the efficiency of nutrient absorption in palm oil. In general, Sigit Dwi Maryanto., S.Si., M.Sc explained that his research will yield short-term downstream products related to molecular markers for nutrient efficiency in palm oil, while the long-term target is nutrient-efficient palm oil progenies. This research significantly contributes to palm oil production.

The culminating event will take place on November 23, 2023, in Jakarta. During this final event, the 12 finalists will present their research, and the winners will be announced. Therefore, Sigit Dwi Maryanto., S.Si., M.Sc hopes to deliver the best performance during the presentation and bring home victory, thereby enhancing the reputation of the Faculty of Biology, Universitas Gadjah Mada. (Vita Meylani, PhD Program Student, First Semester 2023, Faculty of Biology).

Biology student at Faculty Biology UGM made another achievement by winning gold medal for Research Project for College Student and Runner Up-1 for Grand Award Research Project for College Student in 2nd International Conference of Biology for Students (ICOBIOS) x Open Bioproject Competition (OBC) 2023 at Brawijaya University on 12-14 November 2023. This achievement was achieved by a team from Laboratory of Genetics and Breeding, comprised of Azizah Tyas Nugrahanty (Biologi 2020), Bagas Alfian Dwiaryanda (Biologi 2020), dan Lucia Arum Sekar Meysari (Biologi 2020) under guidance Ganies Riza Aristya, S.Si., M.Sc., Ph.D in collaboration with Raden Afif Pranaya Jati, S.P., M.Sc from Indonesia Bioinformatic Institute (INBIO-Indonesia).

The 2nd International Conference of Biology for Students (ICOBIOS) x Open Bioproject Competition (OBC) 2023 has the theme ”Inovative Approach in Investigating Biological Problem through Multidisciplinary Research and Startup” aimed to accelerate collaboration and enhance understanding of various biological aspect for young researchers. The competition was held from July to November 2023 and had several stages, including abstract submission, abstract announcement, proposal submission, presentation and ceremonial event.

The Poly-hydroxy butyrate (PHB) team is examining the issue of biodegradable plastic due to the fact that the development of plastic nowadays is inseparable from modern human life and will grow continuously every year. In addition, various efforts have been undertaken and are being made, one of which is to find alternatives for conventional plastics that are more environmentally friendly and sustainable. Based on these challenges, Azizah, Bagas, and Lucia focus on developing organisms as effective and efficient producers of PHB by utilizing genetic transformation technology. Until now, the PHB team has successfully combined synthetic genes constructed into plasmids into bacterial cells as candidates for naturally producing PHB microbes. This solution is expected to become an alternative to conventional plastics. Furthermore, the team and supervisors also hope that this research will evolve continuously every year to create a comfortable environment without conventional plastics. [Authors: Azizah Tyas Nugrahanty, Bagas Alfian Dwiaryanda, and Lucia Arum Sekar Meysari]

Biology student at Faculty Biology UGM made another achievement by winning silver medal for research idea proposal in 2nd International Conference of Biology for Students (ICOBIOS) x Open Bioproject Competition (OBC) 2023 at Brawijaya University on 12-14 November 2023. This achievement was achieved by Templus team, comprised of Muhammad Helmi Fauzan (Biologi 2020), Nisa Abidah (Biologi 2021), and Anandita Amalia (Biologi 2021) under guidance Dr. Miftahul Ilmi, S.Si., M.Si. in collaboration with Aditya Aryandi an alumnus from Faculty Biology in 2010.

The 2nd International Conference of Biology for Students (ICOBIOS) x Open Bioproject Competition (OBC) 2023 has the theme ”Inovative Approach in Investigating Biological Problem through Multidisciplinary Research and Startup” aimed to accelerate collaboration and enhance understanding of various biological aspect for young researchers. The competition was held from July to November 2023 and had several stages, including abstract submission, abstract announcement, proposal submission, presentation and ceremonial event.

Team Templus addressed the issue of stunting, which is not only rooted in a lack of socialization within communities but also in the insufficient variety of nutrients in daily meals, especially for micronutrients such as vitamin A. On the other hand, the presence of tempe as an affordable food source in Indonesia with sufficient nutrition could be an alternative for food fortification. Therefore, one solution proposed by Team Templus to address the stunting issue is fortifying tempe through genetic engineering using the fermentation agent Rhizopus oryzae induced with precursor genes for carotenoids by Mucor circinelloides.

Though initially encountering confusion in method construction, Team Templus successfully completed the proposal, hoping that the offered solution could likely progress to the research stage and succeed in testing. Subsequently, this solution is anticipated to serve as an alternative to reducing stunting rates in Indonesia. [Author: Anandita Amalia]

Proposing an idea entitled “Smart Integrated Education System of Agrotourism Community Services”, lecturer at the Faculty of Biology UGM, Ganies Riza Aristya, Ph.D., got the Outstanding Flagship Project award at the 2023 RCE Awards for Innovative Projects on Education for Sustainable Development (ESD). The RCE Awards are appreciation award for programs and projects that focus on education for sustainable development. This contribution is a concrete manifestation of overcoming the challenges of sustainable development in the region. Recognized programs are programs that involve the transformation of teaching and research and demonstrate active contribution of society, including the involvement of partners and stakeholders.

Focusing on the development of Sendangsari Village and Sidomulyo Village, Pengasih, Kulon Progo, Ganies and the KKN (Community Service) Team UGM that she coached highlighted the agricultural potential of these two villages in building a Tourism Village based on sustainable agriculture. This potential is also a challenge, where potential local products, in terms of quality and quantity, have experienced a decline after the COVID-19 pandemic. Technology and educational support and the development of MSME products are in the spotlight in developing villages whose communities still depend on the agricultural sector. This is in line with sustainable development goals (SDGs) in increasing decent work and community economic growth (SDG 8). Ganies also highlighted the involvement of Women Farmer Groups (KWT) which play an active role in processing and managing agricultural products, supporting gender equality in village economic development (SDG 5).

Agrotourism is a concept that combines agricultural activities with environmentally friendly tourism and contributes to the economy of the local community within it. Ganies applies the Smart Integrated Education System in agrotourism development, seeking to raise the potential of local communities through various education and training programs (SDG 4), community and stakeholder involvement, and the use of innovative technology. In addition, this concept also supports awareness of environmental conservation and preservation and sustainable agriculture, both for local communities and tourists (SDG 14 and 15).

It is hoped that this idea can create a sustainable agrotourism sector, increase awareness of environmental conservation while promoting local culture and providing economic benefits to local communities.

The UGM-Indonesia team, consisting of students from various faculties at Universitas Gadjah Mada (UGM), has achieved remarkable succes feat by winning a gold medal, inclusivity award, and a nomination for the best diagnostic project at the Grand Jamboree – International Genetically Engineered Machine (iGEM) Competition 2023, held in Paris, France, from November 2 to November 5, 2023. Four out of the sixteen members of the UGM-Indonesia team are Biology students in the class of 2020 : Sofyan Maulana, Fathur Syahrian Ramadhani, Adelia Intan Sabhira, and Ulfah Nur Azizah. This moment marks the first time in the 20-year history of the iGEM competition that a team from Indonesia has successfully secured a special award and entered the nomination for the best project. Previously, in 2021, the UGM-Indonesia team led by Yustika Sari (Biology 2017) achieved a silver medal.

iGEM is a prestigious competition in the field of Synthetic Biology that originated from a summer school activity at the Massachusetts Institute of Technology (MIT) in 2003. In this competition, each team is provided with an iGEM Distribution Kit containing hundreds of “BioBrick Parts,” which are DNA components that can be assembled into genetic circuits to address various real-world problems. This competition has spurred the emergence of research innovations, companies, and leading biotechnology startups such as Ginkgo Bioworks, Asimov, and Benchling. In the two-decade celebration of iGEM, this year’s competition was participated in by 400 teams from 66 countries, involving over 3000 high school students, undergraduate, and graduate students from around the world.

Under the leadership of I Made Rhamandana Putra (Pharmacy 2019), the UGM-Indonesia team adopted the theme of diagnostic technology with a project entitled “Novel Biodevice for Colorectal Cancer Screening using Escherichia coli Nissle 1917 (ECN) with miRNAs as Biomarker”. The team successfully engineered the ECN bacteria to detect cancer cells and enhance the sensitivity of the Loop-Initiated RNA Activator (LIRA) through mathematical modeling and computer simulation. The hard work, innovation, and creativity of this team convinced five international judges to award a gold medal and a nomination for the best diagnostic project. In addition to conducting research in the laboratory, the iGEM team also had to approach social and inclusivity aspects within various community components. Out of the 400 competing teams, the UGM-Indonesia team was selected to win the special prize: the best Inclusive award.

This achievement would not have been possible without the dedication and guidance of various parties. Dr. Yekti Asih Purwestri from the Faculty of Biology UGM served as the main supervisor, supported by Widhi Dyah Sawitri, Ph.D (Faculty of Agriculture), M. Saifur Rohman, Ph.D (Faculty of Agriculture), and Setyowati Triastuti Utami, Ph.D (Faculty of Pharmacy). Additionally, the team was assisted by 15 mentors comprising of lecturers, alumni, and UGM students, including six lecturers from the Faculty of Biology: Dr. Yekti Asih Purwestri, S.Si., M.Si., Dr. Niken Satuti Nur Handayani, Aries Bagus Sasongko, M.Biotech, Lisna Hidayati, M.Biotech, Indra Lesmana, M.Sc., and Matin Nuhamunada, M.Sc. [Author: UGM iGEM Team]

Biology students Universitas Gadjah Mada (S1) made another achievement at national level by win 2nd place in the National Essay Competition (E-Comp) “BIOCOMPACT (Biology Competition and Application) Season 14” held at the State University of Surabaya on October 29, 2023. This remarkable achievement was achieved by Muhammad Fityatul Haq and Ulfah Nur Azizah, Biology Student Class of 2020 under the guidance of Laksmindra Fitria, S.Si., M.Si.

The competition took the theme “The Role of the Younger Generation in Realizing the Millennial Generation (Potential, Critical Thinking, and Innovation)”, aimed to enhancing the knowledge and understanding of the younger generation in advancing the quality of SDGS 2040, particularly in the field of biology, which is closely related to issues concerning living organisms and the environment. The competition underwent a series of selection stages, including essay registration and submission, selection of the top 5 finalists, collection of essay posters, and concluded with the finalists’ presentations. This competition took place from July 3, 2023, to October 29, 2023.

Through this competition, the team highlighted the holistic implementation of Interdisciplinary Project-Based Learning (I-PjBL) amidst educational segmentation, emphasizing its urgency in the context of special needs education. For children with special needs, PjBL can serve as an alternative to enhance their real-life learning experiences, as it is constructivist in nature, particularly in developing critical thinking skills that can encourage them to be more independent and less reliant on others. Additionally, the team also spotlighted the implementation of I-PjBL in STEM-based learning.

The team hopes that the breakthroughs and issues raised through this competition will contribute to achieving the Sustainable Development Goal (SDG) 4, which pertains to inclusive quality education. Furthermore, they aspire that participation in this competition will provide encouragement and motivation for Indonesian students and the younger generation to make positive contributions towards advancing education in Indonesia. [Author: Ulfah Nur Azizah]