The prevalence of adverse drug reactions in Indonesia ranges from 0.9% to 99%, depending on the type of drug, duration, and therapeutic dose. Each individual can respond differently to the same medication due to varying genomic reactions. This concept is known as pharmacogenomics. However, the medical devices used in pharmacogenomics, such as sensors, often cannot reach certain areas within the body. Additionally, a significant challenge in genomic data classification is the vast number of individual genes, which can number in the tens of thousands. Meanwhile, medical devices are limited and often inadequate.

In response to these challenges, Feny, a biology student at UGM, proposed the development of an Integrated Machine Learning-Based Biosensor Pharmacogenomics System as an advanced treatment method for Indonesia under the guidance of Lecturer Tyas Ikhsan Hikmawan, M.Sc., Ph.D.. Her idea was presented at the National Student and School Essay Festival (Genesis) and won the Silver Medal. The competition held by the Fatepa English Community at the University of Mataram on July 6-7, 2024, featured 315 entries. The competition included several stages: submission of a full paper, creation of a presentation video, preparation of a PowerPoint presentation, and a live poster presentation before the judges.

Her innovation involves using biosensors to monitor molecular interactions in patient treatments real-time. These ingestible biosensors provide information about organs’ physiological parameters, allowing them to monitor the genetic profiles related to internal conditions and diseases. The approach employs a random tree classification model that predicts personalized drug responses, side effects, and the patient’s pharmacogenomic variants.

The combination of pharmacogenomic treatment systems with integrated machine-learning biosensors will enhance drug safety. Implementing this system in Indonesia will reduce adverse drug reactions and side effects. Healthcare professionals can quickly monitor patients’ drug intervention responses, enabling them to make the best treatment decisions promptly.
[Author: Feny Nur Nucifera]

On Wednesday, July 31, 2024, the Faculty of Biology UGM opened the series of the PIONIR Metamorphoself 2024, an annual event organized by the Faculty of Biology to welcome young biologists, as an introduction to the faculty and prepare them for their academic journey at UGM. The PIONIR Metamorphoself 2024 carried the theme ‘’Bioadaptability: Realizing a Generation of Pioneer Innovators for the Nation’’. Through this theme, it hoped that young biologists can excel and create in various fields of study, adapting to the transition from school to university.

The first day of PIONIR Metamorphoself began with the opening ceremony at 7:30 AM. The ceremony was opened with a welcome speech from the General Coordinator of PIONIR Metamorphoself 2024, Muhammad Syahrul Firdaus, followed by a speech from the Cluster Coordinator, Tyas Ikhsan Hikmawan, S.Si, M.Si, Ph.D.. Next, there was a speech from the Dean of the Faculty of Biology UGM, Prof. Dr. Budi Setiadi Daryono, M.Agr.Sc and officially opening the PIONIR Metamorphoself 2024, symbolized by the installation of a deer replica at Terra Nova. After the opening ceremony, young biologists attended several sessions.

The first session was a talk with the faculty leadership, Prof. Dr. Budi Setiadi Daryono, M.Agr.Sc., the Dean of the Faculty of Biology, Dr. Bambang Retnoaji, M.Sc, Vice Dean for Academic and Student Affairs, Dr. Slamet Widiyanto, M.Sc., Vice Dean for Finance, Assets, and Human Resources, and Dr. Eko Agus Suyono, M.App.Sc., Vice Dean for Research, Community Service, Cooperation, and Alumni Affairs. This session was moderated by Dr.rer.nat. Abdul Rahman Siregar, S.Si., M.Biotech, aimed to introduce young biologists to the organizational structure, facilities, and assets of the Faculty of Biology. The Vice Deans also explained academic and non-academic activities at the Faculty of Biology, collaborations with national and international institutions, and highlighted successful graduates in various fields.

Next was a session featuring Emi Dwi Suryanti, S.Si, M.Sc, Coordinator for Academic and Student Affairs, and Sukirno, S.Si., M.Sc., Ph.D., Head of the Bachelor in Biology Study Program, provided an overview of administrative systems, lectures, permissions, length of study, and exam requirements. Tips for young biologists to adapt to the Faculty of Biology at UGM were also shared, followed by a Q&A session.

After these sessions, young biologists participated in a quiz based on the materials presented during the leadership and academic coordinator talks. The next session was an introduction to the faculty lecturers, guided by MCs Angga Firza Pratama and Birrul Qisty Mutmainnah Nazara. The faculty lecturers were introduced in sequence according to their laboratories. Following the faculty lecturers introductions, young biologists participated in a bonding session with their Academic Supervisors (DPA). They directed to their DPA’s location based on a faculty map, guided by instructors. During this session, they received information about plagiarism and shared experiences about university life with their DPAs.

The Averin team (Antivenom use Tamarind) from UGM discovered the potential of tamarind seeds (Tamarindus indica) as an alternative treatment for ground snake (Calloselasma rhodostoma) bites. This research was conducted by Oktaviani Nisa Hanafiah (Veterinary Medicine), Fauzela Azira Ainaya (Biology), Fani Nur Maftukhah (Pharmacy), Rahmadina Nur Azizah (Pharmacy), and Khansa Fortuna Putri (Veterinary Medicine). The research was funded by the Ministry of Education, Culture, Research, and Technology (Kemendikbudristek) and Universitas Gadjah Mada. It hoped that this support will help address the issues of access and cost of snake bite treatment.

“This research aims to provide a theoretical foundation and preclinical data on the effectiveness of T. indica seed extract against C. rhodostoma snake bites. The results of this study could contribute to alternative treatments, reducing mortality rates from C. rhodostoma bites in Indonesia,” said Oktaviani.

Oktaviani emphasized the importance and urgency of this research. “According to WHO data, Indonesia experiences around 135,000 snake bite cases annually, with a mortality rate of 5-10%. The C. rhodostoma snake is a significant cause of death in Java. However, the Antivenom Serum (SABU) for these snake bites is not widely available and remains expensive,” Oktaviani added.

The tamarind seed extract was tested in vivo against C. rhodostoma venom, showing that in the group treated with tamarind seed extract, the hemorrhagic area was significantly smaller compared to the group treated with snake venom alone. Therefore, T. indica shows promise as a new treatment for snake bites, especially for C. rhodostoma. Our dedication to this research drives us to continue exploring nature’s potential to enhance human life, Oktaviani stated. These findings were presented at the National Seminar on Tropical Biology (SNBT) on July 20, 2024. [Author: Fauzela Azira Ainaya]

Wednesday, July 24, 2024, The Faculty of Biology, Universitas Gadjah Mada, held a Graduation Ceremony for the Postgraduate Program 2023/2024 period IV at 01.00 p.m.. The event attended by the Vice Dean for Academic and Student Affairs, Dr. Bambang Retnoaji, M.Sc., the Vice Dean for Finance, Assets, and Human Resources, Dr. Slamet Widianto, S.Si., M.Sc., the Vice Dean for Research, Community Service, Collaboration and Alumni Affairs, Dr. Eko Agus Suyono, S.Si., M.App.Sc., the Head of Master in Biology Study Program, Dr.rer.nat. Andhika Puspito Nugroho, S.Si., M.Si., and the Head of Doctor in Biology Study Program, Prof. Dr. Endah Retnaningrum, M.Eng.. The ceremony was opened by the Dean of the Faculty of Biology Prof. Dr. Budi Setyadi Daryono, M.Agr.Sc., and followed by singing Indonesia Raya, Hymne Gadjah Mada, and Faculty of Biology March. The event continued with performances of the traditional dance “Golek Ayun-Ayun” from Daerah Istimewa Yogyakarta.

Then, the graduation report was delivered by the Head of Doctor in Biology Study Program, Prof. Dr. Endah Retnaningrum, M.Eng.. Up to this period, the Postgraduate program of Biology UGM had graduated 136 doctoral students and 1729 master students. In the IV Period of Academic Year 2023/2024, there were 14 graduates for the master program with 11 graduates with cumlaude predicates. The average length of study was one year and 11 months eighteen days, with an average GPA of 3.84. The highest GPA was obtained by Shela Delfia Ramadhana, S.Pd., M.Sc. with a GPA of 3.98, meanwhile, the graduate with the fastest completion time was Siti Shofa Assyifa’ul Qulbi Barid, S.Pd., M.Sc., with a study period of 1 year, 4 months, and 7 days.

Next, there was a reading of the graduate’s graduation results. Furthermore, there was a speech by representatives of the graduates Shofa Assyifa’ul Qulbi Barid, S.Pd., M.Sc. She expressed that the Faculty of Biology has become a second home for graduates to gain knowledge, engage in discussions, serve the community, and conduct scientific research to uphold the Tri Dharma of higher education. On behalf of the graduates, she thanked everyone who supported them through the challenges of postgraduate life. She also apologized for any mistakes made during their studies. She extended heartfelt gratitude to the parents and families of the graduates for their sacrifices and prayers. She noted that this graduation is not the pinnacle of achievement but a small token of appreciation for the parents’ hard work and love. She also thanked friends and companions who added color to their lives. With this graduation, their moral responsibility for their degree increases. She ended her speech by asking for prayers and support for their future endeavors.

The ceremony continued with a remark from the representative of the parents, Captain Bambang Lasito, M.Mar., father of Shela Delfia Ramadhana, S.Pd., M.Sc.. He congratulated and praised the graduates for completing their study with exceptional excellence. He expressed pride in their achievements, which reflect their commitment to knowledge and education. He thanks the lecturers, especially the advisors, for their dedication and the life lessons imparted to the graduates. He also thanked the Faculty of Biology staff for their support and services, which enabled their children to complete their postgraduate studies smoothly. His message to the graduates was to remain humble with their new titles and knowledge, continue learning and innovating for the benefit of society and the nation, and always support and pray for their success. He reminded them that their success was the beginning of future achievements and hoped that Allah SWT would always guide and protect them.

The ceremony continued with a pin awarding as a sign of membership in the Faculty of Biology Family by the Vice Dean for Research, Community Service, Collaboration and Alumni Affairs, Dr. Eko Agus Suyono, S.Si., M.App.Sc., represented by graduates Adam Astiti, S.Si., M.Sc., and Arinda Widi Antari, S.Pd., M.Sc. Following that was a speech by the Dean, Prof. Dr. Budi Setiadi Daryono, M.Agr.Sc. He congratulated the graduates and their parents. Not all parents can afford to educate their children to the level of a master’s. He cited the Organization for Economic Cooperation and Development (OECD) on July 2, which highlighted Indonesia’s demographic trend where there used to be a shortage of S1 degree holders, but now the number of S2 graduates is increasing. S2 graduates, especially from UGM’s accredited Faculty of Biology, are in demand by various institutions, including government, private sectors, and higher education institutions. The faculty’s unique offerings, such as the Master of Science (M.Sc.) degree and publications, provide graduates with a competitive edge. He also mentioned that the faculty offers two further study options: a professional program for biodiversity curatorship, the only one in Asia and Indonesia, addressing environmental and biomedical challenges, and a doctoral program in biology. He emphasized the importance of maintaining ethics and morals and respecting parents. He concluded by expressing gratitude to the lecturers and educational staff for their dedication and prayed for the graduate’s success and benefits to society.

The event continued with a presentation of mementos from the graduates of Period IV, Academic Year 2023/2024, represented by Wildan Alfian Fahmi, S.Si., M.Sc., to the Dean of the Faculty of Biology UGM. The ceremony ended with a prayer by Mr. Sumarno, S.Si., M.Sc., and a group photo. [Author: KMP Biology]

On Monday, July 22, 2024, The Faculty of Biology conducted an introduction to KABIOGAMA and a Tracer Study for prospective graduates of the Postgraduate Program for the fourth period of the 2023/2024 academic year. The event was held online and featured Ganies Riza Aristya, S.Si., M.Sc., Ph.D. as a speaker. She opened the event by congratulating and wishing success to the prospective graduates who had completed their studies. She congratulates their upcoming official induction into the Alumni Family of Universitas Gadjah Mada (KAGAMA) and the Alumni Family of the Faculty of Biology UGM (KABIOGAMA), one of Indonesia’s largest alumni communities. She provided an overview of KABIOGAMA, including the meaning of the KABIOGAMA logo, vision and mission, organizational structure, and regional coordinators available to assist alumni in their hometowns. Mrs. Ganies highlighted several activities actively conducted by KABIOGAMA, such as the “bela beli bolo” initiative (purchasing alumni products), scientific writing seminars, webinars, alumni training, and alumni teaching programs.

In addition to academic activities, KABIOGAMA has contributed to the Faculty of Biology by providing aid, such as assistance for Semeru victims and support for Biology students affected by the COVID-19 pandemic. Contributions have also been made towards building facilities like the Al Hayat Mosque, the Sinar Mas Building, the Kabiogama Pavilion, and supporting activities of KAGAMA, the Faculty of Biology UGM, and the Indonesia Biologist Association. KABIOGAMA also organizes annual alumni reunions.

The second part of the session involved the introduction of UGM’s Tracer Study. Mrs. Ganies explained that in the following year, the faculty would contact the graduates to participate in the Tracer Study. The Tracer Study aimed to improve the curriculum, gather information from alumna on their competency development, inventory the benefits gained by alumna, and track their employment status, job fields, and job levels. Through the Tracer Study, it hoped that alumni could provide feedback on the curriculum’s flexibility at the Faculty of Biology. She also discussed the key performance indicators for higher education institutions, the mechanism for completing the Tracer Study, and the IKU 1 Tracer Study UGM 2024 achievement guidelines.

Mrs. Ganies highlighted UGM’s global reputation, ranking 231st in the World University Rankings for 2023. As a prospective alumni, she encouraged all graduates to join the Simponi platform through SIMASTER, connect with KABIOGAMA’s social media accounts such as Facebook and Instagram, and maintain ties with the Faculty of Biology UGM. During the discussion session, she mentioned that UGM has a career center specifically for the Biology program, which includes the Biology Career and Alumni Development Centre (BCADC) website integrated with Facebook and the Simponi web portal. This platform provides alumni with job and career-related information, usually disseminated via individual emails.

Additionally, Mrs. Ganies emphasized the importance of relationships and collaboration as alumni. She noted that information stems from networks built through cooperation and connections, which can serve as a valuable resource for advancing further. Alumna should leverage information systems, knowledge, and technology to enhance access to information. Collaboration and networking expand the potential benefits, aligning with the motto “Ngawiji wiguanani,” which means “Let us unite to mutually benefit and support each other,” not just for personal but for broader benefits through mutual support and assistance. She also reminded alumna not to hide behind UGM’s prestigious name but to demonstrate their competence and potential to compete with graduates from other universities. Alumna should be confident, leading the way, and upholding UGM’s values and integrity in their professional lives. [Author: KMP Biologi]

The rapid advancement of technology has caused significant concern among the residents of Kampung Terban, particularly in RW 5, due to the rise in juvenile delinquency. Addressing technological advancement requires anticipation and preparation to mitigate its negative impacts. One such negative impact is sexual violence, proven by easy access to pornography on the internet, cases of cybersex, and promiscuity among children and teenagers. Even though Kampung Terban RW 5 is close to Universitas Gadjah Mada (UGM), sexual education has not yet reached the residents of Kampung Terban RW 5. The societal taboo on sex education is a reason sexual education is rarely taught by parents or teachers in schools. However, sexual education is a crucial foundation for reducing cases of sexual violence.

Based on the issue the team from UGM consists of Hafifah Nur Ainiyah (Biology 2022), Aulia Robiatul Adawiyah (Biology 2022), Diyan Ulsa (Psychology 2022), Danila Nur Rahmawati (Environmental Geography 2022), and Alma Puska Falasyifa (Biology 2022), under the guidance of Dr. Dwi Sendi Priyono, S.Si., M.Si conducted community service program titled “SCASE: School of Sexuality Education through Smart Snakes and Ladders Game as a Character-Building Medium for Kampung Terban Residents,” focuses on delivering age-appropriate sexual education, as recommended by WHO, through an interactive Snakes and Ladders game. This method ensures that the material is both well-understood and engaging.

Through the SCASE program, Hafifah and her team aim to enhance the welfare of the local community by empowering Desa Mitra. They use socialization, education, and training with the youth organization Karang Taruna Kampung Terban RW 5 (R05TER). Adina, a member of R05TER, stated, “There is a desire among the community to learn about sexual education, but they are still confused about where to start because it is considered a taboo topic, and there has never been a sexual education outreach program in this village.”

Supriyanto, the head of RW 5 Kampung Terban, said, “This program greatly assists the community, especially parents, who are unsure how to start discussions on sexual education with their children. It has had a very positive impact, particularly on children, who now understand which parts of their bodies should not be touched by others and know how to protect themselves to prevent sexual violence.”

The program expected to provide proper sexual education for residents Kampung Terban RW 5, and the community will be better prepared to face potential cases of sexual violence. It also hoped that the program would inspire other initiatives focused on sexual education, whether by the government or other community empowerment organizations. Author: Hafifah Nur Ainiyah.

Wednesday, July 17, 2024 – SD N Kebonagung, Kanten, Kebonagung, Imogiri, held a socialization event titled “Introduction to Local Flora and Fauna and Their Potential to Students in the School Environment”. The event aimed to introduce local flora and fauna to first-grade students of SD N Kebonagung, encouraging them to explore their surroundings and participate in the School Environment Introduction Period (MPLS). The event was attended by 25 participants, including first-grade students, The SD N Kebonagung school head, Erni Wahyuningsih, S.Pd. Jas., and the Physical Education Teacher, Mr. Frida Endrawanto, S.Pd. This event was also part of a community service program (KKN) supervised by Nur Indah Septriani, S.Si., M.Sc., Ph.D., a lecturer from the Faculty of Biology UGM.

During the event, students were encouraged to appreciate local natural wealth through various educational and interactive activities. By exploring the area around the school, students learned about different types of flora and fauna in their environment and understood the importance of nature conservation.

This activity supports several Sustainable Development Goals (SDGs), including:

In her speech, Mrs. Erni Wahyuningsih, S.Pd. Jas., stated, “We hope that through this activity, our students will not only get to know local flora and fauna better but also grow into a generation that cares about and is responsible for environmental conservation.” Meanwhile, Mr. Frida Endrawanto, S.Pd., added, “Exploring the surroundings as part of MPLS is expected to provide enjoyable and meaningful learning experiences for the students.”

It hoped that SD N Kebonagung students would appreciate and protect local natural wealth more and be inspired to continue learning and contributing to environmental conservation.

The UGM Biology team, consisting of Irfan Agus Nugroho (Biology 2021), Laila Nurul Ilma (Biology 2021), and Fika Zulfiani (Biology 2021), successfully earned a Bronze Medal Quartile nomination in the Scientific Paper competition at the Agritech Research and Entrepreneurship Innovation (AGREETION) 2024. The subtheme of their entry was “Environmental Sustainability Innovation.” AGREETION 2024 is an international scientific paper and business plan competition organized by the Agritech Research and Study Club (ARSC) of the Faculty of Agricultural Technology, Universitas Brawijaya. This year’s theme was “Accelerating Agriculture and Agro-Industry Towards Sustainable Welfare with Eco-Friendly and Clean Production Principles.” Forty-two universities from 3 countries participated in this competition that was held online from April 20 to June 1, 2024.

The team presented an essay titled “Algae Screens: Eco-friendly Sunscreen Based on Red Algae (Palmaria palmata) as an Effort to Prevent Damaged Coral Reef Ecosystems.” The paper was inspired by Indonesia’s abundant coral reefs, which are threatened by degradation, partly due to sunscreen chemicals dissolving in the water. Chemicals in conventional sunscreens, oxybenzone and octinoxate can lead to coral bleaching. As a result, research conducted to develop eco-friendly sunscreen from natural ingredients. The natural compounds focused in this research were Mycosporine-Like Amino Acids (MAAs), abundant in red algae like Palmaria palmata. The research employed a literature study and molecular docking methods between MAA compounds (mycosporine glycine, porphyra-334, and shinorine) as ligands and the target protein Procollagen C-endopeptidase 1 (PCOLCE1). PCOLCE1 is a protein involved in regulating skin aging due to UV exposure, while the three MAA compounds used are known to possess the best antioxidant properties among MAA compounds. The research found that all three MAA compounds could bind to the target protein PCOLCE1, with porphyra-334 being the most effective. Therefore, the Algae-Screen product has the potential to be an effective natural sunscreen alternative to prevent photoaging while being safe for coral reef ecosystems. However, further research is needed to develop and refine the Algae-Screen formulation.

The CEREALGAE team from The Faculty of Biology UGM, led by Hana Salwa (Biology 2022) along with Irfan Agus Nugroho (Biology 2021), successfully won a Silver Medal Quartile at the Agritech Research and Entrepreneurship Innovation (AGREETION) 2024 competition. The AGREETION 2024 is an international scientific paper and business plan competition organized by the Agritech Research and Study Club (ARSC) of the Faculty of Agricultural Technology, Universitas Brawijaya, with the theme ‘’Accelerating Agriculture and Agro-Industry Towards Sustainable Welfare with Eco-Friendly and Clean Production Principles.’’ Forty two universities from 3 countries participated in this competition that was held online from April 20 to June 1, 2024.

The team presented an essay titled “CEREALGAE: Cereal Formulation Based on Brown Algae (Sargassum sp.) Fortified with Moringa Leaves as a Food Diversification Strategy to Prevent Stunting.” The essay was motivated by the high stunting incidence in Indonesia. Aligned with the government’s efforts to achieve Sustainable Development Goals (SDGs) No 2, which aims to end hunger, achieve food security, and improve nutrition, along with the “Gerakan Nasional (GerNas)” program, food diversification can be a preventive measure to ensure that toddlers receive proper nutrition. One approach to achieving this goal is to optimize the utilization of natural ingredients, such as Sargassum sp. and moringa leaves, as functional food ingredients.

Sargassum sp. is a type of brown algae with high abundance and contains macronutrients like carbohydrates, proteins, lipids, and several micronutrients. The protein in Sargassum sp. can aid in cell regeneration during growth and repair, making it recommended for children’s growth phases. Fortifying food with moringa leaf powder can increase the protein, zinc, iron, calcium, and magnesium content. Moringa leaf powder contains about 27.1 g of protein, making it an excellent alternative to animal protein. A study indicates that moringa leaf fortification can significantly increase toddler weight and reduce acute nutrient deficiencies two months after consumption. The Indonesian society’s tendency to consume instant or fast food prompted the biology student team to create a functional food innovation in the form of cereal made from Sargassum sp. and moringa leaves. This innovation is expected to be one solution to reduce the prevalence of stunting in Indonesia through functional food diversification utilizing natural ingredients. Author: Kamilia Hana Salwa.

Universitas Gadjah Mada students Ribka Wijayanti and Dwina Aulia (Dentistry 2022), Anisah Qurrotu Aini (Biology 2022), and Naila Nurfadhilah (Pharmacy 2022) conducted research on the potential of Dayak onion as an antiproliferative and apoptosis-inducing agent for human tongue cancer cells – under the guidance of Prof. drg. Supriatno, M.Kes., MD.Sc., Ph.D..

Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is a medicinal herb commonly used by the indigenous Dayak people and can be cultivated in various regions. Besides health benefits, this research also positively impacts the local economy. This research focuses on developing a natural therapy for tongue cancer by addressing the shortcomings of existing therapy. Plant-derived exosome-like nanoparticles, or PDENs, from Dayak onion, serve as a drug delivery method derived from Dayak onion exosomes.

“Cancer occurs due to the activity of proto-oncogenes, leading to excessive cell proliferation and the inhibition of tumor suppressor genes. We used PDENs because they have proven to inhibit proliferation and induce apoptosis in various types of cancer. Based on this, we wanted to explore its potential for tongue cancer treatment, ‘’ explained Ribka.

Ribka noted that using PDENs from Dayak onion induced apoptosis (programmed cell death) in cancer cells and reduced the number of proliferating cells.

“Dayak onions have a powerful IC50 equivalent to 38.97 ppm. This value is superior to other medicinal plants, such as soursop leaves and bajakah roots. The various therapeutic compounds in Dayak onion cannot be utilized as therapeutic agents using common extraction methods. However, with PDENs, all therapeutic compounds can be delivered to the target organ,” Anisah elaborated.

This research project was submitted as part of the Student Creativity Program in Exact Research (PKM-RE) with research funding support from the Ministry of Education, Culture, Research, and Technology (Kemendikbudristek) to conduct in-depth research and analysis on the potential of PDENs extract from Dayak onion. It hoped that this interdisciplinary collaborative research can inspire further exploration of natural potentials to improve human quality of life. [Writer: AQA]